Parkinson's disease[ edit ] In its pill form, selegiline is used to treat symptoms of Parkinson's disease. This avoids an inhibition of gastrointestinal and hepatic MAO-A activity resulting in an increase in blood of food-borne tyramine and possible adverse effects, while sufficient amount of selegiline reach the brain for an antidepressant effect.
Indocin Mobic Pristiq peut altérer votre pensée ou vos réactions. Soyez prudent si vous conduisez ou faites quelque chose qui vous oblige à être vigilant. Évitez l'exposition à la lumière du soleil ou aux lits de bronzage.
The LHH for remission vs. This increases susceptibility to side effects of non-selective MAOIssuch as tyramine -induced hypertensive crisis and serotonin toxicity when combined with serotonergic medications.
Additionally, in post-marketing surveillance from April to Octoberonly 13 self-reports of possible hypertensive events or hypertension were made out of 29, exposures to the drug, and none were accompanied by objective clinical data. They cross the blood—brain barrier and enter the brain, where they most concentrated at the thalamusbasal gangliamidbrainand cingulate gyrus.
Due to the presence of these metabolites, people taking selegiline may test positive for "amphetamine" or "methamphetamine" on drug screening tests. A newer anti-Parkinson MAO-B inhibitor, rasagilinemetabolizes into 1 R -aminoindan, which has no amphetamine-like characteristics.
Transdermal dosing results in significantly higher exposure to selegiline and lower exposure to all metabolites when compared to oral dosing; this is due to the extensive first-pass metabolism of the pill form emsam provoque-t-il une perte de poids low first-pass metabolism of the patch form. The site of application is not a significant factor in how the drug is distributed.
These types of drugs are not meant to be discontinued this way, and this is why you have the dizziness and other effects. I am not a big person either so even 10 's shows. Talk to you doctor about any unpleasant side effects you experience from your medications.
In humans, selegiline does not accumulate in the skin, nor is it metabolized there. The compound is a derivative of levomethamphetamine L -methamphetamine with a propargyl group attached to the nitrogen atom. This detail is borrowed from pargylinean older MAO-B inhibitor of the phenethylamine group.
Selegiline is synthesized by the alkylation of — -methamphetamine using propargyl bromide. History[ edit ] Following the discovery that the tuberculosis drug iproniazid elevated the mood of people taking it, and the subsequent discovery that the effect was likely due to inhibition of MAOmany people and companies started trying to discover MAO inhibitors to use as antidepressants.
Mais attention! A vous de voir ce qui ne va pas : sédentarité? Les prises alimentaires en dehors des repas : mine de rien, les grignotages, les collations, et plus généralement les prises alimentaires en dehors des repas apportent beaucoup de calories. Les prises alimentaires déclenchées par les contrariétés, le stress, les émotions.
Selegiline was discovered by Zoltan Ecseri at the Hungarian drug company, Chinoin part of Sanofi since which they called E Further work determined that the levorotatory enantiomer was a more potent MAO-inhibitor, which was published inand subsequent work was done with the single enantiomer L -deprenyl.
A few years later, two Parkinson's disease researchers based in Vienna, Peter Riederer and Walther Birkmayer, realized that selegiline could be useful in Parkinson's disease.
One of their colleagues, Prof. Moussa B. Youdimvisited Knoll in Budapest and took selegiline from him to Vienna.
16 Antidépresseurs qui entraînent une prise de poids
InBirkmayer's group published the first paper on the effect of selegiline in Parkinson's disease. Alexander Bodkin at McLean Hospitalan affiliate of Harvard Medical Schoolbegan a collaboration with Somerset to develop delivery of selegiline via a transdermal patch in order to avoid the well known dietary restrictions of MAO inhibitors.
Veterinary use[ edit ] In veterinary medicineselegiline is sold under the brand name Anipryl manufactured by Zoetis. It is used in dogs to treat canine cognitive dysfunction and, at higher doses, pituitary -dependent hyperadrenocorticism PDH. Geriatric dogs treated with selegiline show improvements in sleeping pattern, reduced incontinence, and increased activity level; most show improvements by one month.
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- Selegiline - Wikipedia
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